Does Spironolactone Cause Infertility

Does spironolactone cause infertility? The drug spirolactone, which is mostly prescribed to treat heart failure, high blood pressure, and edema (fluid retention), has drawn interest and sparked concerns about possible effects on fertility. There are worries about spironolactone’s effects on reproductive health and potential for infertility, especially among those who are taking it for the treatment of acne. To clarify the connection between spironolactone and infertility, we examine the scientific data in this article.

What is Spironolactone

Spironolactone is a member of the potassium-sparing diuretic drug class. It functions by preventing the hormone aldosterone from acting, which controls the body’s salt and water balance. Spironolactone lowers blood pressure and relieves edema by inhibiting aldosterone and assisting the body in getting rid of extra fluid and salt.

Spironolactone’s medicinal uses

Spironolactone is prescribed for a number of illnesses, such as:

  • Hypertension (high blood pressure)
  • Heart failure
  • Edema associated with liver cirrhosis or nephrotic syndrome
  • Hormonal condition known as primary aldosteronism
  • Polycystic ovary syndrome (PCOS) – particularly for hirsutism (excessive hair growth) and acne treatment in women.

Does Spironolactone Cause Infertility?

Does spironolactone cause infertility? The discussion over spironolactone’s possible effect on fertility mostly arises from the fact that it is used to treat acne, especially in women who are or will become pregnant. The anti-androgenic qualities of spironolactone have sparked some worries since they may alter hormone levels, particularly testosterone.

It is important to distinguish between theoretical issues and empirical data, nevertheless. Although there are theoretical issues, there is few and conflicting actual data to establish a direct association between spironolactone usage and infertility.

Studies on Spironolactone and Fertility

The findings of studies examining the impact of spironolactone on fertility have been conflicting.

Studies on Animals

A few research conducted on animals have indicated that spironolactone may have negative effects on fertility and reproductive organs. Nevertheless, further study is required because it is unclear how applicable these findings are to people.

Studies on Human

There aren’t many human research looking at how spironolactone affects fertility. The reproductive results of women with acne treated with spironolactone were assessed in a retrospective cohort research that was published in the Journal of Drugs in Dermatology in 2015. The results of the trial did not reveal any appreciable variations in the reproductive outcomes of women who received spironolactone vs those who did not.

Clinical Guidelines and Recommendations

Healthcare providers should use caution when administering spironolactone to women of reproductive age, especially if there is a worry about potential negative effects on fertility, notwithstanding the scant data. Owing to the paucity of information on spironolactone’s safety during pregnancy, it is often suggested that women who are planning a pregnancy or who are already pregnant stop taking the medication. It is also urged that women using effective contraception take it while taking spironolactone.


There is still much to learn and discuss about the connection between spironolactone and infertility. Although there are theoretical worries about how it can affect fertility, there isn’t enough actual data to prove a clear causal link. To definitively explain the effects of spironolactone on reproductive health, further study is required, especially well planned prospective trials. Healthcare professionals should, in the interim, assess the possible advantages and disadvantages of spironolactone usage individually for each patient, taking into account their preferences and unique circumstances.

Also Read: Infertility Awareness Month – Everything You Need to Know

Written by

Dr Hoorain

Hoorain Batul is a passionate and experienced writer specializing in gynecology, obstetrics, fashion, and women's wellness. Hailing from Pakistan, she holds an MBBS degree, having completed her studies in 2011, and has furthered her expertise with FCPS Part 1 and 2. With a deep understanding of women's health and a keen eye for fashion, Hoorain brings a unique perspective to her content, providing valuable insights and empowering women with knowledge to lead healthier and more fashionable lives. Her content is a hub of informative and engaging articles, catering to the diverse needs of women worldwide.